Factors for starting biosimilar TNF inhibitors in patients with rheumatic diseases in the real worldopen access
- Authors
- Sung, Yoon-Kyoung; Jung, Sun-Young; Kim, Hyoungyoung; Choi, Seongmi; Im, Seul Gi; Lee, Yu Sang; Jang, Eun Jin; Cho, Soo-Kyung
- Issue Date
- Jan-2020
- Publisher
- Public Library of Science
- Citation
- PLoS ONE, v.15, no.1
- Journal Title
- PLoS ONE
- Volume
- 15
- Number
- 1
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/37960
- DOI
- 10.1371/journal.pone.0227960
- ISSN
- 1932-6203
- Abstract
- Background To identify factors for starting biosimilar TNF inhibitors (TNFI) in patients with rheumatic diseases. Methods and finding Using a national claims database, we identified patients with rheumatoid arthritis (RA) or ankylosing spondylitis (AS) who had used TNFIs since they were approved in Korea in 2004. We assessed changes in the proportion of each form of TNFI used between 2004 and 2017. We then selected patients starting on TNFIs between 2013 and 2017 to identify factors for starting biosimilars. In RA (n = 4,216), biosimilars were more likely to be initiated in clinics [odds ratio (OR) 2.54] and in the metropolitan area (OR, 2.02), but were less likely to be initiated in general hospitals (OR 0.40) or orthopedics (OR 0.44). In AS (n = 2,338), biosimilars were common at the hospital level (OR 2.20) and tended to increase over the years (OR 1.16), but were initiated less in orthopedics (OR 0.07). In addition, RA patients were more likely to initiate biosimilars in combination with methotrexate (OR 1.37), but biosimilars were not initiated frequently by patients with higher comorbidity scores (OR 0.97) or receiving glucocorticoids (OR 0.67). The patient factors favoring biosimilar in AS use were not clear. Conclusions In Korea, the proportion of biosimilar TNFIs has increased. Type of institution and physician specialty are more important than patient factors in affecting biosimilar use. In RA, biosimilar TNFIs tend to be initiated in combination with MTX, and are less likely to be initiated in patients taking glucocorticoids or in those with high comorbidities. © 2020 Sung et al.
- Files in This Item
-
- Appears in
Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/37960)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.