식물 유래 당단백질의 당질 구조 분석Structural Analysis of Oligosaccharides of a Plant Glycoprotein
- Authors
- 배재우; 박병태; 윤두천; 김주영; 황혜성; 박현주; 나종천; 김하형
- Issue Date
- Dec-2010
- Publisher
- 대한약학회
- Keywords
- plant glycoprotein; oligosaccharide; structure
- Citation
- 약 학 회 지, v.54, no.6, pp 449 - 454
- Pages
- 6
- Journal Title
- 약 학 회 지
- Volume
- 54
- Number
- 6
- Start Page
- 449
- End Page
- 454
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/38049
- ISSN
- 0377-9556
- Abstract
- The glycosylation of glycoproteins from mammalian or plants can affect their efficacy, stability, solubility, and half-life. In the present study, we investigated plant glycosylation and their relative intensity (%) in a plant carbohydratebinding protein with the hemagglutination and antiproliferative activities. The hemagglutination activity on the deglycosylated protein was decreased as a 16-fold than that of intact glycoprotein. Using the HPLC with fluorescence detector and mass spectrometer, the major eight bi- or triantennary oligosaccharides containing xylose, fucose, mannose, galactose,and N-acetylglucosamine were identified and structurally characterized. The present results indicate that the oligosaccharides on this plant glycoprotein is necessary for their own property.
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Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
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