Hepatoprotective effects of Lactococcus chungangensis CAU 1447 in alcoholic liver disease
- Authors
- Nam, Y.; Kim, J.-H.; Konkit, M.; Kim, Wonyong
- Issue Date
- Dec-2019
- Publisher
- Elsevier Inc.
- Keywords
- alcoholic liver disease; antioxidant activity; cream cheese; Lactococcus chungangensis CAU 1447; toll-like receptor
- Citation
- Journal of Dairy Science, v.102, no.12, pp 10737 - 10747
- Pages
- 11
- Journal Title
- Journal of Dairy Science
- Volume
- 102
- Number
- 12
- Start Page
- 10737
- End Page
- 10747
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/38686
- DOI
- 10.3168/jds.2019-16891
- ISSN
- 0022-0302
1525-3198
- Abstract
- Alcoholic liver disease (ALD) is correlated with alcohol consumption, and ALD progression depends on various factors. Some lactic acid bacteria (LAB) are beneficial for mitigating ALD. However, the valuable effects of LAB-derived dairy products remain unclear. Here, we evaluated the effects of Lactococcus chungangensis CAU 1447 dry cells (CAU 1447) and cream cheese derived from CAU 1447 on ALD progression following long-term alcohol consumption in rats. Oral administration of CAU 1447 and CAU 1447 cream cheese significantly reduced alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, and triglyceride levels. We found that CAU 1447 and CAU 1447 cream cheese downregulated mRNA encoding various cytokines and antioxidative factors in the liver. Oral CAU 1447 cream cheese administration increased short-chain fatty acid, butyrate, and acetate levels in feces. Thus, administration of CAU 1447 and CAU 1447 cream cheese induced hepatoprotective effects, indicating potential applications as a supplement for ALD mitigation. © 2019 American Dairy Science Association
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > College of Medicine > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/38686)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.