Variability of the Composition of Growth Factors and Cytokines in Platelet-Rich Plasma From the Knee With Osteoarthritis
DC Field | Value | Language |
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dc.contributor.author | Ha, Chul-Won | - |
dc.contributor.author | Park, Yong-Beom | - |
dc.contributor.author | Jang, Jae Won | - |
dc.contributor.author | Kim, Manyoung | - |
dc.contributor.author | Kim, Jin-A. | - |
dc.contributor.author | Park, Yong-Geun | - |
dc.date.available | 2020-04-20T02:22:09Z | - |
dc.date.issued | 2019-10 | - |
dc.identifier.issn | 0749-8063 | - |
dc.identifier.issn | 1526-3231 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/38729 | - |
dc.description.abstract | Purpose: To investigate the composition and concentration of growth factors and cytokines in platelet-rich plasma (PRP) with knee osteoarthritis and to explore the association of the concentration of growth factors and cytokines with the platelet count of PRPs. Methods: Patients who visited outpatient clinic with symptomatic knee osteoarthritis (Kellgren-Lawrence grades 1 to 3) and had no blood dyscrasia were enrolled from October 2014 to March 2015. PRPs were obtained using a commercial system. Concentrations of growth factors and cytokines were measured with an enzyme-linked immunosorbent assay. Anabolic factors (platelet-derived growth factor [PDGF]-AA, -BB, and -AB, transforming growth factor-beta, vascular endothelial growth factor [VEGF], epidermal growth factor [EGF], basic fibroblast growth factor [bFGF], and insulin-like growth factor 1), catabolic factors (interleukin [IL]-1 beta and matrix metalloproteinase 13), and catabolic blockers (IL-1 receptor antagonist) were included. The degree of variation was determined by coefficient of variation (CoV). Results: 105 patients were included. Growth factors and cytokines showed wide variation. bFGF showed the highest variation (CoV 78.45), and transforming growth factor-beta 1 showed the lowest variation (CoV 5.30). Platelet count in PRP showed a positive correlation with PDGF-BB and -AB, and VEGF (r = 0.270, P =.005; r = 0.231, P =.018; and r = 0.200, P =.041, respectively) and was negatively correlated with IL-1 beta (r = e0.220, P =.025). Conclusion: Growth factors and cytokines in PRPs obtained from patients with knee osteoarthritis show a wide variation; the highest variation was shown in bFGF. Platelet counts associated positively with PDGF-AB and -BB and VEGF and negatively with IL-1 beta. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | W B SAUNDERS CO-ELSEVIER INC | - |
dc.title | Variability of the Composition of Growth Factors and Cytokines in Platelet-Rich Plasma From the Knee With Osteoarthritis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.arthro.2019.04.010 | - |
dc.identifier.bibliographicCitation | ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY, v.35, no.10, pp 2878 - 2884.e1 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000489268900023 | - |
dc.identifier.scopusid | 2-s2.0-85072968274 | - |
dc.citation.endPage | 2884.e1 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 2878 | - |
dc.citation.title | ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY | - |
dc.citation.volume | 35 | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | CELLULAR COMPOSITION | - |
dc.subject.keywordPlus | CLASSIFICATION | - |
dc.subject.keywordPlus | REGENERATION | - |
dc.subject.keywordPlus | CHONDROCYTES | - |
dc.subject.keywordPlus | BONE | - |
dc.relation.journalResearchArea | Orthopedics | - |
dc.relation.journalResearchArea | Sport Sciences | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Orthopedics | - |
dc.relation.journalWebOfScienceCategory | Sport Sciences | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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