Variability of the Composition of Growth Factors and Cytokines in Platelet-Rich Plasma From the Knee With Osteoarthritis
- Authors
- Ha, Chul-Won; Park, Yong-Beom; Jang, Jae Won; Kim, Manyoung; Kim, Jin-A.; Park, Yong-Geun
- Issue Date
- Oct-2019
- Publisher
- W B SAUNDERS CO-ELSEVIER INC
- Citation
- ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY, v.35, no.10, pp 2878 - 2884.e1
- Journal Title
- ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
- Volume
- 35
- Number
- 10
- Start Page
- 2878
- End Page
- 2884.e1
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/38729
- DOI
- 10.1016/j.arthro.2019.04.010
- ISSN
- 0749-8063
1526-3231
- Abstract
- Purpose: To investigate the composition and concentration of growth factors and cytokines in platelet-rich plasma (PRP) with knee osteoarthritis and to explore the association of the concentration of growth factors and cytokines with the platelet count of PRPs. Methods: Patients who visited outpatient clinic with symptomatic knee osteoarthritis (Kellgren-Lawrence grades 1 to 3) and had no blood dyscrasia were enrolled from October 2014 to March 2015. PRPs were obtained using a commercial system. Concentrations of growth factors and cytokines were measured with an enzyme-linked immunosorbent assay. Anabolic factors (platelet-derived growth factor [PDGF]-AA, -BB, and -AB, transforming growth factor-beta, vascular endothelial growth factor [VEGF], epidermal growth factor [EGF], basic fibroblast growth factor [bFGF], and insulin-like growth factor 1), catabolic factors (interleukin [IL]-1 beta and matrix metalloproteinase 13), and catabolic blockers (IL-1 receptor antagonist) were included. The degree of variation was determined by coefficient of variation (CoV). Results: 105 patients were included. Growth factors and cytokines showed wide variation. bFGF showed the highest variation (CoV 78.45), and transforming growth factor-beta 1 showed the lowest variation (CoV 5.30). Platelet count in PRP showed a positive correlation with PDGF-BB and -AB, and VEGF (r = 0.270, P =.005; r = 0.231, P =.018; and r = 0.200, P =.041, respectively) and was negatively correlated with IL-1 beta (r = e0.220, P =.025). Conclusion: Growth factors and cytokines in PRPs obtained from patients with knee osteoarthritis show a wide variation; the highest variation was shown in bFGF. Platelet counts associated positively with PDGF-AB and -BB and VEGF and negatively with IL-1 beta.
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