Endogenous n-3 Polyunsaturated Fatty Acids Are Beneficial to Dampen CD8(+) T Cell-Mediated Inflammatory Response upon the Viral Infection in Miceopen access
- Authors
- Kang, Kyung Won; Kim, Seyoung; Cho, Yong-Bin; Ryu, Seung Rok; Seo, Young-Jin; Lee, Sang-Myeong
- Issue Date
- Sep-2019
- Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
- Keywords
- omega-3; CD8+ T cell; LCMV; immunopathology
- Citation
- International Journal of Molecular Sciences, v.20, no.18
- Journal Title
- International Journal of Molecular Sciences
- Volume
- 20
- Number
- 18
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/38989
- DOI
- 10.3390/ijms20184510
- ISSN
- 1661-6596
1422-0067
- Abstract
- Omega-3 (n-3) polyunsaturated fatty acids (PUFAs) have been known to exert anti-inflammatory effects on various disease states. However, its effect on CD8(+) T cell-mediated immunopathology upon viral infection has not been well elucidated yet. In this study, we investigated the possible implication of n-3 PUFAs in CD8(+) T cell responses against an acute viral infection. Infection of FAT-1 transgenic mice that are capable of synthesizing n-3 PUFAs from n-6 PUFAs with lymphocytic choriomeningitis virus (LCMV) resulted in significant reduction of anti-viral CD8(+) T cell responses. Interestingly, expansion of adoptively transferred wild-type (WT) LCMV-specific T cell receptor (TCR) transgenic CD8(+) (P14) T cells into FAT-1 mice was significantly decreased. Also, activation of anti-viral CD4(+) helper T cells was reduced in FAT-1 mice. Importantly, P14 cells carrying the fat-1 gene that were adoptively transferred into WT mice exhibited a substantially decreased ability to proliferate and produce cytokines against LCMV infection. Together, n-3 PUFAs attenuated anti-viral CD8(+) T cell responses against an acute viral infection and thus could be used to alleviate immunopathology mediated by the viral infection.
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