Structural insights on retroviral DNA integration: Learning from foamy virusesopen access
- Authors
- Lee, Ga-Eun; Mauro, Eric; Parissi, Vincent; Shin, Cha-Gyun; Lesbats, Paul
- Issue Date
- Sep-2019
- Publisher
- MDPI AG
- Keywords
- Foamy virus; Integrase; Integration; Retrovirus
- Citation
- Viruses, v.11, no.9
- Journal Title
- Viruses
- Volume
- 11
- Number
- 9
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/38998
- DOI
- 10.3390/v11090770
- ISSN
- 1999-4915
1999-4915
- Abstract
- Foamy viruses (FV) are retroviruses belonging to the Spumaretrovirinae subfamily. They are non-pathogenic viruses endemic in several mammalian hosts like non-human primates, felines, bovines, and equines. Retroviral DNA integration is a mandatory step and constitutes a prime target for antiretroviral therapy. This activity, conserved among retroviruses and long terminal repeat (LTR) retrotransposons, involves a viral nucleoprotein complex called intasome. In the last decade, a plethora of structural insights on retroviral DNA integration arose from the study of FV. Here, we review the biochemistry and the structural features of the FV integration apparatus and will also discuss the mechanism of action of strand transfer inhibitors. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
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Collections - College of Biotechnology & Natural Resource > Department of Systems Biotechnology > 1. Journal Articles
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