Beneficial effects of a medicinal herb, Cirsium japonicum var. maackii, extract and its major component, cirsimaritin on breast cancer metastasis in MDA-MB-231 breast cancer cells
- Authors
- Park, Jun Yeon; Kim, Hyun Young; Shibamoto, Takayuki; Jang, Tae Su; Lee, Sang Cheon; Shim, Jae Suk; Hahm, Dae-Hyun; Lee, Hae-Jeung; Lee, Sanghyun; Kang, Ki Sung
- Issue Date
- Sep-2017
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Cirsium japonicum var. maackii; Cirsimaritin; Breast cancer; Metastasis; Natural plant extract
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.27, no.17, pp 3968 - 3973
- Pages
- 6
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 27
- Number
- 17
- Start Page
- 3968
- End Page
- 3973
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/3957
- DOI
- 10.1016/j.bmcl.2017.07.070
- ISSN
- 0960-894X
1464-3405
- Abstract
- The biological activities of the ethanol extract from Cirsium japonicum var. maackii (ICF-1) and its major component, polyphenol cirsimaritin, were investigated as part of the search for possible alternative drugs for breast cancer. Three in vitro cell-based assays were used: the cell proliferation assay, tube-formation assay, and Western blot analysis. Both the ICF-1 extract and cirsimaritin inhibited the viability of HUVECs in a dose-dependent manner. The inhibition achieved was 36.89% at a level of 200 mu g/ml by the ICF-1 extract and 62.04% at a level of 100 mu M by cirsimaritin. The ICF-1 extract and cirsimaritin reduced tube formation by 12.69% at level of 25 mu g/ml and 32.18% at the levels of 6.25 mu M, respectively. Cirsimaritin inhibited angiogenesis by downregulation of VEGF, p-Akt and p-ERK in MDA-MB-231 cells, suggesting that cirsimaritin is potentially useful as an anti-metastatic agent. The present study demonstrated that Cirsium japonicum extract and its active component cirsimaritin is an excellent candidate as an alternative anti-breast cancer drug. (C) 2017 Elsevier Ltd. All rights reserved.
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