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2×2 교차설계에 의한 생물학적 동등성 시험에서 결측치가 있을 때의 통계적 해석 방법Statistical Interpretation of Bioequivalence in 2×2 Crossover Design with Missing Observations
- Issue Date
- Oct-2004
- Publisher
- 한국약제학회
- Keywords
- Bioequivalence; Incomplete 2?´?2 crossover design; Maximum likelihood estimators
- Citation
- 약제학회지, v.34, no.5, pp 379 - 383
- Pages
- 5
- Journal Title
- 약제학회지
- Volume
- 34
- Number
- 5
- Start Page
- 379
- End Page
- 383
- ISSN
- 2093-5552
2093-6214
- Abstract
- Statistical interpretations in a bioequivalence trial are considered and studied when the missing observations occurred in 2 × 2 crossover experiment. Patel (1985) suggested the approximate test procedures for carryover effect and drug effect in 2 × 2 crossover design when some of data are missing in the second period. A modified Patel method is newly pro-posed to the bioequivalence trial and it is compared with the current method through the simulation study.
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