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Bioequivalence for 2×2 Crossover Experiment with Missing ObservationsBioequivalence for Crossover Experiment with Missing Observations
- Issue Date
- Aug-2004
- Publisher
- 한국통계학회
- Keywords
- bioequivalence; incomplete 2×2 crossover design; maximum likelihood estimators; bootstrap confidence intervals; bioequivalence; incomplete 2×2 crossover design; maximum likelihood estimators; bootstrap confidence intervals
- Citation
- CSAM(Communications for Statistical Applications and Methods), v.11, no.2, pp 235 - 246
- Pages
- 12
- Journal Title
- CSAM(Communications for Statistical Applications and Methods)
- Volume
- 11
- Number
- 2
- Start Page
- 235
- End Page
- 246
- ISSN
- 2287-7843
- Abstract
- Statistical models and their inferences in a bioequivalence trial are considered and studied when the missing observations occurred in 2? crossover experiment. Patel(1985) suggested the approximate test procedures for carryover effect and drug effect in 2? crossover design. Bootstrap methods are proposed to implement Patel`s test to the bioequivalence trial. Patel`s work and its bootstrap methods are discussed with the current KFDA rule through the simulation studies and the recommendation is made.
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