Reducing agent-free synthesis of curcumin-loaded albumin nanoparticles by self-assembly at room temperature
DC Field | Value | Language |
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dc.contributor.author | Safavi, Maryam Sadat | - |
dc.contributor.author | Shojaosadati, Seyed Abbas | - |
dc.contributor.author | Yang, Hye Gyeong | - |
dc.contributor.author | Kim, Yejin | - |
dc.contributor.author | Park, Eun Ji | - |
dc.contributor.author | Lee, Kang Choon | - |
dc.contributor.author | Na, Dong Hee | - |
dc.date.available | 2019-03-08T07:58:31Z | - |
dc.date.issued | 2017-08 | - |
dc.identifier.issn | 0378-5173 | - |
dc.identifier.issn | 1873-3476 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/4061 | - |
dc.description.abstract | The purpose of this study was to prepare curcumin-loaded bovine serum albumin nanoparticles (CCM-BSA-NPs) by reducing agent-free self-assembly at room temperature. A 24 factorial design approach was used to investigate the CCM-BSA-NP preparation process at different pH values, temperatures, dithiothreitol amounts, and CCM/BSA mass ratios. Increasing the ionic strength enabled preparation of CCM-BSA-NPs at 25 degrees C without reducing agent. CCM-BSA-NPs prepared under the optimized conditions at 25 degrees C showed a particle size of 110 +/- 6 nm, yield of 88.5%, and drug loading of 7.1%. The CCM-BSA-NPs showed strong antioxidant activity and neuroprotective effects in glutamate-induced mouse hippocampal neuronal HT22 cells. This study suggests that ionic strength can be a key parameter affecting the preparation of albumin-based NPs. (C) 2017 Elsevier B.V. All rights reserved. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Reducing agent-free synthesis of curcumin-loaded albumin nanoparticles by self-assembly at room temperature | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.ijpharm.2017.06.087 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF PHARMACEUTICS, v.529, no.1-2, pp 303 - 309 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000408009200028 | - |
dc.identifier.scopusid | 2-s2.0-85023168374 | - |
dc.citation.endPage | 309 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 303 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF PHARMACEUTICS | - |
dc.citation.volume | 529 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | Albumin nanoparticles | - |
dc.subject.keywordAuthor | Antioxidant activity | - |
dc.subject.keywordAuthor | Curcumin | - |
dc.subject.keywordAuthor | Neuroprotective effect | - |
dc.subject.keywordAuthor | Self-assembly | - |
dc.subject.keywordPlus | DRUG-DELIVERY-SYSTEMS | - |
dc.subject.keywordPlus | ANTICANCER DRUG | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | OPTIMIZATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | PACLITAXEL | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | SURFACE | - |
dc.subject.keywordPlus | CELLS | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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