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Reducing agent-free synthesis of curcumin-loaded albumin nanoparticles by self-assembly at room temperature
- Authors
- Safavi, Maryam Sadat; Shojaosadati, Seyed Abbas; Yang, Hye Gyeong; Kim, Yejin; Park, Eun Ji; Lee, Kang Choon; Na, Dong Hee
- Issue Date
- Aug-2017
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Albumin nanoparticles; Antioxidant activity; Curcumin; Neuroprotective effect; Self-assembly
- Citation
- INTERNATIONAL JOURNAL OF PHARMACEUTICS, v.529, no.1-2, pp 303 - 309
- Pages
- 7
- Journal Title
- INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Volume
- 529
- Number
- 1-2
- Start Page
- 303
- End Page
- 309
- ISSN
- 0378-5173
1873-3476
- Abstract
- The purpose of this study was to prepare curcumin-loaded bovine serum albumin nanoparticles (CCM-BSA-NPs) by reducing agent-free self-assembly at room temperature. A 24 factorial design approach was used to investigate the CCM-BSA-NP preparation process at different pH values, temperatures, dithiothreitol amounts, and CCM/BSA mass ratios. Increasing the ionic strength enabled preparation of CCM-BSA-NPs at 25 degrees C without reducing agent. CCM-BSA-NPs prepared under the optimized conditions at 25 degrees C showed a particle size of 110 +/- 6 nm, yield of 88.5%, and drug loading of 7.1%. The CCM-BSA-NPs showed strong antioxidant activity and neuroprotective effects in glutamate-induced mouse hippocampal neuronal HT22 cells. This study suggests that ionic strength can be a key parameter affecting the preparation of albumin-based NPs. (C) 2017 Elsevier B.V. All rights reserved.
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