n-3 Polyunsaturated Fatty Acids Impede the TCR Mobility and the TCR-pMHC Interaction of Anti-Viral CD8+ T Cells
DC Field | Value | Language |
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dc.contributor.author | Lim, Younghyun | - |
dc.contributor.author | Kim, Seyoung | - |
dc.contributor.author | Kim, Sehoon | - |
dc.contributor.author | Kim, Dong-In | - |
dc.contributor.author | Kang, Kyung Won | - |
dc.contributor.author | Hong, So-Hee | - |
dc.contributor.author | Lee, Sang-Myeong | - |
dc.contributor.author | Koh, Hye Ran | - |
dc.contributor.author | Seo, Young-Jin | - |
dc.date.available | 2020-08-03T06:25:09Z | - |
dc.date.issued | 2020-06 | - |
dc.identifier.issn | 1999-4915 | - |
dc.identifier.issn | 1999-4915 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/42719 | - |
dc.description.abstract | The immune-suppressive effects of omega-3 (n-3) polyunsaturated fatty acids (PUFAs) on T cells have been observed via multiple in vitro and in vivo models. However, the precise mechanism that causes these effects is still undefined. In this study, we investigated whether n-3 PUFAs regulated T cell receptor (TCR) and peptide-major histocompatibility complex (pMHC) interactions. The expansion of anti-viral CD8+ T cells that endogenously synthesize n-3 PUFAs (FAT-1) dramatically decreased upon lymphocytic choriomeningitis virus (LCMV) infection in vivo. This decrease was not caused by the considerable reduction of TCR expression or the impaired chemotactic activity of T cells. Interestingly, a highly inclined and laminated optical sheet (HILO) microscopic analysis revealed that the TCR motility was notably reduced on the surface of the FAT-1 CD8+ T cells compared to the wild type (WT) CD8+ T cells. Importantly, the adhesion strength of the FAT-1 CD8+ T cells to the peptide-MHC was significantly lower than that of the WT CD8+T cells. Consistent with this result, treatment with docosahexaenoic acid (DHA), one type of n-3 PUFA, significantly decreased CD8+ T cell adhesion to the pMHC. Collectively, our results reveal a novel mechanism through which n-3 PUFAs decrease TCR-pMHC interactions by modulating TCR mobility on CD8+ T cell surfaces. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | NLM (Medline) | - |
dc.title | n-3 Polyunsaturated Fatty Acids Impede the TCR Mobility and the TCR-pMHC Interaction of Anti-Viral CD8+ T Cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/v12060639 | - |
dc.identifier.bibliographicCitation | Viruses, v.12, no.6 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000551253600001 | - |
dc.identifier.scopusid | 2-s2.0-85086686835 | - |
dc.citation.number | 6 | - |
dc.citation.title | Viruses | - |
dc.citation.volume | 12 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | omega-3 | - |
dc.subject.keywordAuthor | CD8+ T cells | - |
dc.subject.keywordAuthor | LCMV | - |
dc.subject.keywordAuthor | TCR-pMHC interaction | - |
dc.subject.keywordPlus | DIETARY FISH-OIL | - |
dc.subject.keywordPlus | CD4+ T-CELLS | - |
dc.subject.keywordPlus | MEMBRANE-FLUIDITY | - |
dc.subject.keywordPlus | DOCOSAHEXAENOIC ACID | - |
dc.subject.keywordPlus | IMPAIRED RESISTANCE | - |
dc.subject.keywordPlus | TRANSGENIC MICE | - |
dc.subject.keywordPlus | PUFA | - |
dc.subject.keywordPlus | OMEGA-3-FATTY-ACIDS | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | SUPPRESS | - |
dc.relation.journalResearchArea | Virology | - |
dc.relation.journalWebOfScienceCategory | Virology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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