Impact of diabetes duration and degree of carotid artery stenosis on major adverse cardiovascular events: a single-center, retrospective, observational cohort study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Noh, Minsu | - |
dc.contributor.author | Kwon, Hyunwook | - |
dc.contributor.author | Jung, Chang Hee | - |
dc.contributor.author | Kwon, Sun U. | - |
dc.contributor.author | Kim, Min Seon | - |
dc.contributor.author | Lee, Woo Je | - |
dc.contributor.author | Park, Joong Yeol | - |
dc.contributor.author | Han, Youngjin | - |
dc.contributor.author | Kim, Hyangkyoung | - |
dc.contributor.author | Kwon, Tae-Won | - |
dc.contributor.author | Cho, Yong-Pil | - |
dc.date.available | 2019-03-08T08:38:06Z | - |
dc.date.issued | 2017-06 | - |
dc.identifier.issn | 1475-2840 | - |
dc.identifier.issn | 1475-2840 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/4339 | - |
dc.description.abstract | Background: We aimed to investigate the impact of diabetes duration and carotid artery stenosis (CAS) on the occurrence of major adverse cardiovascular events (MACE) in patients with type 2 diabetes mellitus (T2DM) without clinical cardiovascular disease. Methods: A total of 2006 patients with T2DM, without clinical cardiovascular disease, aged >50 years, and who underwent baseline carotid Doppler ultrasound screening with regular follow-ups at the outpatient clinic of our diabetes center, were stratified into four subgroups according to diabetes duration and CAS degree. The primary outcomes included the occurrence of MACE, defined as fatal or nonfatal stroke and myocardial infarction, and all-cause mortality. Results: The difference in the MACE incidence was significantly greater in patients with a longer diabetes duration (>= 10 years) and significant CAS (50-69% luminal narrowing) (p < 0.001). Analysis of individual MACE components indicated a trend towards an increased incidence of stroke (p < 0.001), parallel to a longer diabetes duration and significant CAS. In contrast, the risk of myocardial infarction was significantly higher in patients with a diabetes duration < 10 years and significant CAS (p = 0.039). Multivariate regression analysis showed that patients with both a longer diabetes duration and significant CAS demonstrated additive and very high risks of MACE (hazard ratio [HR], 2.07; 95% confidence interval [CI] 1.17-3.66; p = 0.012) and stroke (HR, 3.38; 95% CI 1.54-7.44; p = 0.002). Conclusions: The risk of MACE is significantly greater in patients with T2DM, without clinical cardiovascular disease, who have both a longer diabetes duration and significant CAS, compared with those who have a shorter duration and/or nonsignificant CAS. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | BIOMED CENTRAL LTD | - |
dc.title | Impact of diabetes duration and degree of carotid artery stenosis on major adverse cardiovascular events: a single-center, retrospective, observational cohort study | - |
dc.type | Article | - |
dc.identifier.doi | 10.1186/s12933-017-0556-0 | - |
dc.identifier.bibliographicCitation | CARDIOVASCULAR DIABETOLOGY, v.16, no.1 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000403105000003 | - |
dc.identifier.scopusid | 2-s2.0-85020258494 | - |
dc.citation.number | 1 | - |
dc.citation.title | CARDIOVASCULAR DIABETOLOGY | - |
dc.citation.volume | 16 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Cardiovascular diseases | - |
dc.subject.keywordAuthor | Carotid artery stenosis | - |
dc.subject.keywordAuthor | Diabetes mellitus | - |
dc.subject.keywordPlus | CORONARY-HEART-DISEASE | - |
dc.subject.keywordPlus | ALL-CAUSE MORTALITY | - |
dc.subject.keywordPlus | PRIOR MYOCARDIAL-INFARCTION | - |
dc.subject.keywordPlus | RISK-FACTORS | - |
dc.subject.keywordPlus | NORTHERN MANHATTAN | - |
dc.subject.keywordPlus | MEDIA THICKNESS | - |
dc.subject.keywordPlus | PLAQUE AREA | - |
dc.subject.keywordPlus | OLDER MEN | - |
dc.subject.keywordPlus | ATHEROSCLEROSIS | - |
dc.subject.keywordPlus | STROKE | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.