Systems metabolic engineering of microorganisms for natural and non-natural chemicals
- Authors
- Lee, Jeong Wook; Na, Dokyun; Park, Jong Myoung; Lee, Joungmin; Choi, Sol; Lee, Sang Yup
- Issue Date
- Jun-2012
- Publisher
- NATURE PUBLISHING GROUP
- Citation
- NATURE CHEMICAL BIOLOGY, v.8, no.6, pp 536 - 546
- Pages
- 11
- Journal Title
- NATURE CHEMICAL BIOLOGY
- Volume
- 8
- Number
- 6
- Start Page
- 536
- End Page
- 546
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/43516
- DOI
- 10.1038/NCHEMBIO.970
- ISSN
- 1552-4450
1552-4469
- Abstract
- Growing concerns over limited fossil resources and associated environmental problems are motivating the development of sustainable processes for the production of chemicals, fuels and materials from renewable resources. Metabolic engineering is a key enabling technology for transforming microorganisms into efficient cell factories for these compounds. Systems metabolic engineering, which incorporates the concepts and techniques of systems biology, synthetic biology and evolutionary engineering at the systems level, offers a conceptual and technological framework to speed the creation of new metabolic enzymes and pathways or the modification of existing pathways for the optimal production of desired products. Here we discuss the general strategies of systems metabolic engineering and examples of its application and offer insights as to when and how each of the different strategies should be used. Finally, we highlight the limitations and challenges to be overcome for the systems metabolic engineering of microorganisms at more advanced levels.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of ICT Engineering > School of Integrative Engineering > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/43516)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.