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Single Walled Carbon Nanotube-Based Electrical Biosensor for the Label-Free Detection of Pathogenic Bacteria
- Authors
- Yoo, Seung Min; Baek, Youn-Kyoung; Shin, SunHaeRa; Kim, Ju-Hyun; Jung, Hee-Tae; Choi, Yang-Kyu; Lee, Sang Yup
- Issue Date
- Jun-2016
- Publisher
- AMER SCIENTIFIC PUBLISHERS
- Keywords
- Single-Walled Carbon Nanotube; Electrical Detection; Bacteria; DNA; Biosensor
- Citation
- JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, v.16, no.6, pp 6520 - 6525
- Pages
- 6
- Journal Title
- JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
- Volume
- 16
- Number
- 6
- Start Page
- 6520
- End Page
- 6525
- ISSN
- 1533-4880
1533-4899
- Abstract
- We herein describe the development of a single-walled carbon nanotube (SWNT)-based electrical biosensor consisting of a two-terminal resistor, and report its use for the specific, label-free detection of pathogenic bacteria via changes in conductance. The ability of this biosensor to recognize different pathogenic bacteria was analyzed, and conditions were optimized with different probe concentrations. Using this system, the reference strains and clinical isolates of Staphylococcus aureus and Escherichia coli were successfully detected; in both cases, the sensor showed a detection limit of 10 CFU. This SWNT-based electrical biosensor will prove useful for the development of highly sensitive and specific handheld pathogen detectors.
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