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Patterned Multiplex Pathogen DNA Detection by Au Particle-on-Wire SERS Sensor
- Issue Date
- Apr-2010
- Publisher
- AMER CHEMICAL SOC
- Keywords
- DNA; multiplex; pathogen; pattern; surface-enhanced Raman scattering
- Citation
- NANO LETTERS, v.10, no.4, pp 1189 - 1193
- Pages
- 5
- Journal Title
- NANO LETTERS
- Volume
- 10
- Number
- 4
- Start Page
- 1189
- End Page
- 1193
- ISSN
- 1530-6984
1530-6992
- Abstract
- A Au particle-on-wire system that can be used as a specific, sensitive, and multiplex DNA sensor is developed. A pattern formed by multiple Au nanowire sensors provides positional address and identification for each sensor. By using this system, multiplex sensing of target DNAs was possible in a quantitative manner with a detection limit of 10 pM. Target DNAs from reference bacteria and clinical isolates were successfully identified by this sensor system, enabling diagnostics for infectious diseases.
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