Sex Differences in Outcomes Following Endovascular Treatment for Symptomatic Peripheral Artery Disease: An Analysis From the K-VIS ELLA Registryopen access
- Authors
- Choi, Ki Hong; Park, Taek Kyu; Kim, Jihoon; Ko, Young-Guk; Yu, Cheol Woong; Yoon, Chang-Hwan; Lee, Jae-Hwan; Min, Pil-Ki; Koh, Yoon Seok; Chae, In-Ho; Choi, Donghoon; Choi, Seung-Hyuk; Kang, Woong Chol; Her, Sung-Ho; Hwang, Byung-Hee; Her, Ae-Young; Kim, Weon; Jo, Sang Cheol; Shin, Sanghoon; Cho, Yun Hyeong; Chung, Woo-Young; Han, Jung Kyu; Lee, Seung Whan; Choi, Seung Hyuk; Choi, Young Jin; Kim, Su Hyun; Park, Sang Ho; Ahn, Chul-Min; Yoon, Young Jin; Lee, Jung-Hee; Choi, Yu Jeong; Ryu, Sung Kee; Kim, Ju Han; Lee, Sang-Rok; Won, Hoyoun; Baek, Ju Yeol; Bae, Jang-Hwan; Kim, Hyun-Sook
- Issue Date
- Jan-2019
- Publisher
- WILEY
- Keywords
- endovascular treatment; peripheral artery disease; outcomes; percutaneous transluminal angioplasty; sex
- Citation
- JOURNAL OF THE AMERICAN HEART ASSOCIATION, v.8, no.2
- Journal Title
- JOURNAL OF THE AMERICAN HEART ASSOCIATION
- Volume
- 8
- Number
- 2
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/43601
- DOI
- 10.1161/JAHA.118.010849
- ISSN
- 2047-9980
2047-9980
- Abstract
- Background-With advances in peripheral artery disease (PAD) treatments such as endovascular treatment (EVT), personalized patient assessment is important. Data on sex differences in clinical outcome for PAD patients undergoing EVT have been limited, and studies have produced conflicting results. This study sought to compare midterm clinical outcomes between women and men in a large population of patients with PAD undergoing EVT. Methods and Results-The K-VIS ELLA (Korean Vascular Intervention Society Endovascular Therapy in Lower Limb Artery Disease) registry is a nationwide, multicenter, observational study that includes 3073 PAD patients undergoing EVT. The study population was divided into men (n=2523) and women (n=550). The primary outcome was a composite of death, myocardial infarction, and major amputation; the secondary outcome included major adverse limb events. Women had more comorbidities and more severe and complex target lesions than men. Women showed higher rates of death, myocardial infarction, or major amputation than men (14.8% versus 9.8%, adjusted hazard ratio 1.350, 95% Cl 1.017-1.792, P-0.038), and higher rates of major adverse limb events (19.9% versus 14.5%, adjusted hazard ratio 1.301, 95% CI 1.014-1.670, P-0.039) and procedural complications (10.2% versus 5.9%, P<0.001) based on multivariable analysis. In patients with claudication, the primary outcome incidence was significantly higher in women (hazard ratio 2.088, 95% Cl 1.421-3.068, P<0.001). In contrast, there was no significant difference in primary outcome for patients with critical limb ischemia between the 2 groups (hazard ratio 1.164, 95% Cl 0.800-1.694, P-0.426). A significant interaction (P-0.035) between patient presentation and outcome was observed. Conclusions-In a large population of patients with PAD undergoing EVT, women had higher rates of death, myocardial infarction, or major amputation than men and higher rates of complex lesions, procedural complications, and limb-specific adverse events.
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