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Vasoactive intestinal peptide (VIP) and VIP mRNA decrease in the cerebral cortex of nNOS knock-out(-/-) mice
- Issue Date
- Jul-2003
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- vasoactive intestinal peptide (VIP); nitric oxide (NO); cerebral cortex; neuronal nitric oxide synthase (nNOS) knock-out(-/-) mice
- Citation
- BRAIN RESEARCH, v.978, no.1-2, pp 233 - 240
- Pages
- 8
- Journal Title
- BRAIN RESEARCH
- Volume
- 978
- Number
- 1-2
- Start Page
- 233
- End Page
- 240
- ISSN
- 0006-8993
1872-6240
- Abstract
- Although there is much evidence showing that NO regulates the release of VIP in several areas, there is no report about the influence of NO on VIP in the cerebral cortex. We therefore examined changes in VIP expression in the cerebral cortex of nNOS knock-out(-/-) mice using immunohistochemistry and in situ hybridization. The nNOS((-/-)) mice had significantly fewer VIP-immunoreactive neurons than the control mice and the VIP mRNA as well as the VIP-immunoreactivity of the individual neuron was decreased in the nNOS((-/-)) mice. The first demonstration of decrease in VIP expression in the cerebral cortex of nNOS((-/-)) mice may provide useful data for investigating the relation between NO and VIP in the cerebral cortex and the mechanisms of many functions of these two neurotransmitters. (C) 2003 Elsevier Science B.V. All rights reserved.
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