Region-specific alterations in insulin-like growth factor receptor type I in the cerebral cortex and hippocampus of aged rats
- Authors
- Chung, YH; Shin, CM; Joo, KM; Kim, MJ; Cha, CI
- Issue Date
- Aug-2002
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- insulin-like growth factor-I (IGF-I); IGF-I receptor; aging; cerebral cortex; hippocampus; immunohistochemistry
- Citation
- BRAIN RESEARCH, v.946, no.2, pp 307 - 313
- Pages
- 7
- Journal Title
- BRAIN RESEARCH
- Volume
- 946
- Number
- 2
- Start Page
- 307
- End Page
- 313
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/43826
- DOI
- 10.1016/S0006-8993(02)03041-X
- ISSN
- 0006-8993
1872-6240
- Abstract
- In the present study, we investigated age-related changes in IGF-I receptor localization in the cerebral cortex and hippocampus of Sprague-Dawley rats using immunohistochemistry. In the cerebral cortex of adult rats, weakly stained cells were seen in layers II-III and layer V/VI in several cortical regions. In aged rats, there was a significant increase in IGF-I receptor immunoreactivity in the pyramidal cells in the same cortical regions. In the hippocampus of adult rats, several moderately stained neurons were seen in CA1-3 areas and the dentate gyrus. Levels of IGF-I receptor protein increased substantially with age in the CA3 area of the hippocampus. Our first morphological data concerning the differential regulation of IGF-I receptors in aged cerebral cortex and hippocampus may provide insights into age-related changes in trophic support as well as basic knowledge required for the study of neurodegenerative diseases such as Alzheimer's disease. (C) 2002 Elsevier Science B.V. All rights reserved.
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