Immunohistochemical study on the aggregation of ubiquitin in the central nervous system of the transgenic mice expressing a human Cu/Zn SOD mutation
- Authors
- Chung, YH; Joo, KM; Lee, YJ; Kim, MJ; Cha, CI
- Issue Date
- Jun-2003
- Publisher
- FOREFRONT PUBL GROUP
- Keywords
- amyotrophic lateral sclerosis; SOD1(G93A) transgenic mice; ubiquitin; central nervous system; immunohistochemistry
- Citation
- NEUROLOGICAL RESEARCH, v.25, no.4, pp 395 - 400
- Pages
- 6
- Journal Title
- NEUROLOGICAL RESEARCH
- Volume
- 25
- Number
- 4
- Start Page
- 395
- End Page
- 400
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/43842
- DOI
- 10.1179/016164103101201553
- ISSN
- 0161-6412
1743-1328
- Abstract
- In the present study, we performed immunohistochemical techniques to investigate the changes in ubiquitin expression in the central nervous system of the transgenic mice expressing a human superoxide dismutase 1 mutation (SOD1)(G93A). Sections of brains from control mice showed virtually no immunostaining for ubiquitin, whereas sections from SOD1(G93A) transgenic mice contained numerous granular or linear deposits of ubiquitin. A high density of the processes containing ubiquitin was detected all around the gray matter of the spinal cord of the mutant transgenic mice. Ubiquitin immunoreactivity was also detected in the cerebellum, brainstem and midbrain of transgenic mice. The first demonstration of the distribution of ubiquitin in the whole brains of the transgenic mice may provide clues for understanding the neuronal degeneration mechanism in amyotrophic lateral sclerosis and other neurodegenerative diseases.
- Files in This Item
-
- Appears in
Collections - College of Medicine > College of Medicine > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.