Immunohistochemical study on the distribution of alpha-synuclein in the central nervous system of transgenic mice expressing a human Cu/Zn superoxide dismutase mutation
- Authors
- Chung, YH; Joo, KM; Kim, MJ; Cha, CI
- Issue Date
- May-2003
- Publisher
- ELSEVIER SCI IRELAND LTD
- Keywords
- amyotrophic lateral sclerosis; transgenic mice; alpha-synuclein; spinal cord; hippocampus; inummohistochemistry
- Citation
- NEUROSCIENCE LETTERS, v.342, no.3, pp 151 - 154
- Pages
- 4
- Journal Title
- NEUROSCIENCE LETTERS
- Volume
- 342
- Number
- 3
- Start Page
- 151
- End Page
- 154
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/43843
- DOI
- 10.1016/S0304-3940(03)00237-4
- ISSN
- 0304-3940
1872-7972
- Abstract
- We used the SOD1(G93A) transgenic mice as an in vivo model of amyotrophic lateral sclerosis (ALS) and performed immunohistochemical studies to investigate whether alpha-synuclein is involved in the pathogenesis of ALS. In the spinal cord of transgenic mice, immunohistochemistry showed intense staining of alpha-synuclein mainly in the anterior horn. In the hippocampus of transgenic mice, differential increases in the staining density of alpha-synuclein were observed. In the cerebellar cortex of transgenic mice, the prominent immunostaining of alpha-synuclein was found in the molecular and granular layers. The present study provides the first in vivo evidence that alpha-synuclein immunoreactivity was increased in the central nervous system of SODG93A transgenic mice, suggesting that a-synuclein might play an important role in the pathogenesis of ALS. However, the functional implications of these increases require elucidation. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
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