A glimpse into the interactions of cells in a microenvironment: the modulation of T cells by mesenchymal stem cellsopen access
- Authors
- Choi, Jonghoon; Hwang, Mintai P.; Lee, Jong-Wook; Lee, Kwan Hyi
- Issue Date
- May-2014
- Publisher
- DOVE MEDICAL PRESS LTD
- Keywords
- mesenchymal stem cell; T cell; microwell array
- Citation
- INTERNATIONAL JOURNAL OF NANOMEDICINE, v.9, pp 127 - 139
- Pages
- 13
- Journal Title
- INTERNATIONAL JOURNAL OF NANOMEDICINE
- Volume
- 9
- Start Page
- 127
- End Page
- 139
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/43889
- DOI
- 10.2147/IJN.S50767
- ISSN
- 1176-9114
1178-2013
- Abstract
- Mesenchymal stem cells (MSCs) have been thought to hold potential as a mode of therapy for immuno-related pathologies, particularly for autoimmune diseases. Despite their potential, the interaction between MSCs and T cells, key players in the pathophysiology of autoimmune diseases, is not yet well understood, thereby preventing further clinical progress. A major obstacle is the highly heterogeneous nature of MSCs in vitro. Unfortunately, bulk assays do not provide information with regard to cell-cell contributions that may play a critical role in the overall cellular response. To address these issues, we investigated the interaction between smaller subsets of MSCs and CD4 T cells in a microwell array. We demonstrate that MSCs appear capable of modulating the T cell proliferation rate in response to persistent cell-cell interactions, and we anticipate the use of our microwell array in the classification of subpopulations within MSCs, ultimately leading to specific therapeutic interventions.
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Collections - College of ICT Engineering > School of Integrative Engineering > 1. Journal Articles
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