Effects of repetitive transcranial magnetic stimulation on improvement of mental health and clinical parameters in depressed hemodialysis patients: A pilot studyopen access
- Authors
- Hwang, J.H.; Hwang, H.; Kim, H.R.; Hong, J.S.; Han, D.H.; Shin, J.; Kim, S.H.; Kim, S.M.
- Issue Date
- Jul-2020
- Publisher
- Korean Academy of Medical Science
- Keywords
- Depression; Hemodialysis; Kidney; Quantitative electroencephalogram; Transcranial magnetic stimulation
- Citation
- Journal of Korean Medical Science, v.35, no.26
- Journal Title
- Journal of Korean Medical Science
- Volume
- 35
- Number
- 26
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/44371
- DOI
- 10.3346/JKMS.2020.35.E205
- ISSN
- 1011-8934
1598-6357
- Abstract
- Background: This study aimed to evaluate the therapeutic effect of repetitive transcranial magnetic stimulation (rTMS) as a nonpharmacologic treatment in depressed hemodialysis patients. Methods: Patients who scored ≥ 5 on the Patient Health Questionnaire-9 were randomized to either the rTMS (n = 7) or sham group (n = 7). The rTMS group was stimulated with a 110% motor threshold and 10 Hz on the left dorsolateral prefrontal cortex for 20 minutes, three times a week, for 4 weeks. In the sham group, the 1-wing 90-degree method was used. We analyzed clinical indices before and after the intervention, as well as data from quantitative electroencephalography (frontal alpha asymmetry [FAA]), and various psychiatric questionnaires (Beck Depression Inventory-II, Beck Anxiety Inventory [BAI], Symptom Checklist-90-Revised Somatization Subscale [SCL-90R-SOM]), and Perceived Stress Scale. Results: One month after rTMS, the changes in hemoglobin A1c levels in the rTMS group were significantly greater than those in the sham group (F = 6.687, P = 0.032). The changes in BAI scores in the rTMS group were significantly greater than those in the sham group (F = 6.700, P = 0.025), and the changes in SCL-90R-SOM scores in the rTMS group were greater than those in the sham group (F = 4.943, P = 0.048). In addition, the changes in the FAA value at the F7 and F8 electrodes in the rTMS group were greater than those in the sham group (F = 6.468, P = 0.027). Conclusion: In depressed hemodialysis patients, rTMS may improve anxiety and somatization symptoms, which may lead to improvements in clinical measures. © 2020 The Korean Academy of Medical Sciences.
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