Detailed Information
Cited 0 time in 
Cited 0 time in 
Cited 0 time in
Metadata Downloads
Critical Roles of E2F3 in Growth and Musculo-skeletal Phenotype in Miceopen access
- Authors
- Kim, Hae-Rim; Rahman, Faiz Ur; Kim, Kwang-Soo; Kim, Eun-Kyeung; Cho, Sang-Mi; Lee, Kihoon; Moon, Ok-sung; Seo, Young-won; Yoon, Won-Kee; Won, Young-Suk; Kang, Hoyoung; Kim, Hyoung-Chin; Nam, Ki-Hoan
- Issue Date
- Oct-2019
- Publisher
- IVYSPRING INT PUBL
- Keywords
- E2f3(+/- )Knockout; Development; Growth retardation; skeletal imperfection; Mouse phenotype
- Citation
- INTERNATIONAL JOURNAL OF MEDICAL SCIENCES, v.16, no.12, pp 1557 - 1563
- Pages
- 7
- Journal Title
- INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
- Volume
- 16
- Number
- 12
- Start Page
- 1557
- End Page
- 1563
- ISSN
- 1449-1907
- Abstract
- E2F3, a member of the E2F family, plays a critical role in cell cycle and proliferation by targeting downstream, retinoblastoma (RB) a tumor suppressor family protein. The purpose of this study, was to investigate the role and function of E2F3 in vivo. We examined phenotypic abnormalities, by deletion of the E2f3 gene in mice. Complete ablation of the E2F3 was fully penetrant, in the pure C57BL/6N background. The E2f3(+/-) mouse embryo developed normally without fatal disorder. However, they exhibited reduced body weight, growth retardation, skeletal imperfection, and poor grip strength ability. Findings suggest that E2F3 has a pivotal role in muscle and bone development, and affect normal mouse growth.
- Files in This Item
- Appears in
Collections - ETC > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.