Self-Assembled Nanoconstructs Modified with Amplified Aptamers Inhibited Tumor Growth and Retinal Vascular Hyperpermeability via Vascular Endothelial Growth Factor Capturing
- Authors
- Lee, Jihyun; Lee, Byung Joo; Lee, Yeong Mi; Park, Hansoo; Kim, Jeong Hun; Kim, Won Jong
- Issue Date
- May-2017
- Publisher
- AMER CHEMICAL SOC
- Keywords
- anti-VEGF therapy; DNA nanoconstructs; polymer-DNA conjugates; antitumor therapy; retinal vascular hyperpermeability
- Citation
- MOLECULAR PHARMACEUTICS, v.14, no.5, pp 1460 - 1468
- Pages
- 9
- Journal Title
- MOLECULAR PHARMACEUTICS
- Volume
- 14
- Number
- 5
- Start Page
- 1460
- End Page
- 1468
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/4496
- DOI
- 10.1021/acs.molpharmaceut.6b00949
- ISSN
- 1543-8384
1543-8392
- Abstract
- Here, nanoconstructs consisting of a DNA- amplified aptamer with a biocompatible polymer backbone for capturing target biomolecules are presented. First, the polymer-DNA nanoconstructs were prepared by hybridization of two complementary single-stranded DNAs that were each conjugated to a dextran polymer backbone. The designed polymer-DNA amplified aptamer nanoconstructs (PA-aNCs) were then prepared by utilizing polymer-DNA nanoconstructs conjugated with an aptamer (PA-NCs) using a rolling circle amplification reaction to amplify the aptamer. These PA-aNCs were successfully applied to alleviate tumor growth and vascular endothelial growth factor (VEGF)induced retinal vascular hyperpermeability in vivo through the highly effective capture of human VEGF as a target molecule. These PA-aNCs could be used as therapeutic agent for anti-VEGF therapy by efficiently capturing human VEGF.
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