Cleft Alveolus Reconstruction Using a Three-Dimensional Printed Bioresorbable Scaffold With Human Bone Marrow Cells
- Authors
- Ahn, Geunseon; Lee, Jeong-Seok; Yun, Won-Soo; Shim, Jin-Hyung; Lee, Ui-Lyong
- Issue Date
- Oct-2018
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- Bioresorbable scaffold; cleft alveolus reconstruction; human bone marrow cells; three-dimensional printing
- Citation
- JOURNAL OF CRANIOFACIAL SURGERY, v.29, no.7, pp 1880 - 1883
- Pages
- 4
- Journal Title
- JOURNAL OF CRANIOFACIAL SURGERY
- Volume
- 29
- Number
- 7
- Start Page
- 1880
- End Page
- 1883
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/45104
- DOI
- 10.1097/SCS.0000000000004747
- ISSN
- 1049-2275
1536-3732
- Abstract
- Bone tissue engineering technology based on scaffold has been applied for cleft lip and palate treatment. However, clinical applications of patient-specific three-dimensional (3D) scaffolds have rarely been performed. In this study, a clinical case using patient-specific 3D-printed bioresorbable scaffold with bone marrow stromal cells collected from iliac crest in the operating room has been introduced. At 6-month after transplantation, the bone volume of the newly regenerated bone was approximately 45% of the total defect volume. Bone mineral density of the newly regenerated bone was about 75% compared to the surrounding bone. The Hounsfield unit value was higher than that of cancellous maxillary alveolar bone and lower than that of the cortical maxillary alveolar bone. Bone-marrow-derived mesenchymal stem cells-seeded 3D-printed patient-specific polycaprolactone scaffolds offer a promising alternative for alveolar cleft reconstruction and other bony defects.
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