A novel voxel-wise lesion segmentation technique on 3.0-T diffusion MRI of hyperacute focal cerebral ischemia at 1h after permanent MCAO in rats
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Chi-Hoon | - |
dc.contributor.author | Yi, Kyung Sik | - |
dc.contributor.author | Lee, Sang-Rae | - |
dc.contributor.author | Lee, Youngjeon | - |
dc.contributor.author | Jeon, Chang-Yeop | - |
dc.contributor.author | Hwang, Jinwoo | - |
dc.contributor.author | Lee, Chulhyun | - |
dc.contributor.author | Choi, Sung Sik | - |
dc.contributor.author | Lee, Hong Jun | - |
dc.contributor.author | Cha, Sang-Hoon | - |
dc.date.accessioned | 2021-06-18T07:41:59Z | - |
dc.date.available | 2021-06-18T07:41:59Z | - |
dc.date.issued | 2018-08 | - |
dc.identifier.issn | 0271-678X | - |
dc.identifier.issn | 1559-7016 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/45219 | - |
dc.description.abstract | To assess hyperacute focal cerebral ischemia in rats on 3.0-Tesla diffusion-weighted imaging (DWI), we developed a novel voxel-wise lesion segmentation technique that overcomes intra- and inter-subject variation in apparent diffusion coefficient (ADC) distribution. Our novel technique involves the following: (1) intensity normalization including determination of the optimal type of region of interest (ROI) and its intra- and inter-subject validation, (2) verification of focal cerebral ischemic lesions at 1h with gross and high-magnification light microscopy of hematoxylin-eosin (H&E) pathology, (3) voxel-wise segmentation on ADC with various thresholds, and (4) calculation of dice indices (DIs) to compare focal cerebral ischemic lesions at 1h defined by ADC and matching H&E pathology. The best coefficient of variation was the mode of the left hemisphere after normalization using whole left hemispheric ROI, which showed lower intra- (2.54 +/- 0.72%) and inter-subject (2.67 +/- 0.70%) values than the original. Focal ischemic lesion at 1h after middle cerebral artery occlusion (MCAO) was confirmed on both gross and microscopic H&E pathology. The 83 relative threshold of normalized ADC showed the highest mean DI (DI=0.820 +/- 0.075). We could evaluate hyperacute ischemic lesions at 1h more reliably on 3-Tesla DWI in rat brains. | - |
dc.format.extent | 13 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SAGE PUBLICATIONS INC | - |
dc.title | A novel voxel-wise lesion segmentation technique on 3.0-T diffusion MRI of hyperacute focal cerebral ischemia at 1h after permanent MCAO in rats | - |
dc.type | Article | - |
dc.identifier.doi | 10.1177/0271678X17714179 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, v.38, no.8, pp 1371 - 1383 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000440674900009 | - |
dc.identifier.scopusid | 2-s2.0-85046029939 | - |
dc.citation.endPage | 1383 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1371 | - |
dc.citation.title | JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | - |
dc.citation.volume | 38 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Brain ischemia | - |
dc.subject.keywordAuthor | diffusion-weighted MRI | - |
dc.subject.keywordAuthor | animal models | - |
dc.subject.keywordAuthor | brain imaging | - |
dc.subject.keywordAuthor | acute stroke | - |
dc.subject.keywordPlus | MAGNETIC-RESONANCE ANGIOGRAPHY | - |
dc.subject.keywordPlus | ARTERY OCCLUSION | - |
dc.subject.keywordPlus | IMAGE SEGMENTATION | - |
dc.subject.keywordPlus | STROKE MODELS | - |
dc.subject.keywordPlus | CELL-DEATH | - |
dc.subject.keywordPlus | COEFFICIENT | - |
dc.subject.keywordPlus | EVOLUTION | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | TRANSIENT | - |
dc.subject.keywordPlus | PERFUSION | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.