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Spontaneous Biomacromolecule Absorption and Long-Term Release by Graphene Oxideopen access

Authors
Tanum, JunjiraHeo, JiwoongHong, Jinkee
Issue Date
May-2018
Publisher
AMER CHEMICAL SOC
Citation
ACS OMEGA, v.3, no.5, pp 5903 - 5909
Pages
7
Journal Title
ACS OMEGA
Volume
3
Number
5
Start Page
5903
End Page
5909
URI
https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/45283
DOI
10.1021/acsomega.8b00537
ISSN
2470-1343
Abstract
Biomacromolecule loading is the popular research in the biomedical field. To control the loading amount and releasing profile, various materials and fabrication techniques were developed. In this study, layer-by-layer assembly of multilayer films between collagen (Col) and graphene oxide (GO) was used to control the release of the loading molecule. By mixing GO into the system, ovalbumin (OVA) can be spontaneously adsorbed onto the GO sheet (denoted as GO/OVA) via the hydrophobic interaction. Two kinds of multilayer films (Col/GO/OVA and Col/GO/OVA) were fabricated. The thickness growth curve, quantitative of each layer adsorption, film morphology, stability, cell viability, and OVA release from multilayer films were investigated. The result has shown excellent film stability, macromolecule loading, and sustained release because of GO ability.
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