Structure of a Multilayer Nanofilm To Increase the Encapsulation Efficiency of Basic Fibroblast Growth Factor
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Han, Uiyoung | - |
dc.contributor.author | Hong, Jinkee | - |
dc.date.accessioned | 2021-06-18T07:43:13Z | - |
dc.date.available | 2021-06-18T07:43:13Z | - |
dc.date.issued | 2018-03 | - |
dc.identifier.issn | 1543-8384 | - |
dc.identifier.issn | 1543-8392 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/45313 | - |
dc.description.abstract | In this study, we established the structure of a multilayer nanofilm that more efficiently encapsulates basic fibroblast growth factor (bFGF). First, a positively charged layer material was selected from biocompatible polymers such as collagen (Col), poly(beta-amino ester) (Poly2), and chitosan (Chi), while considering the film thickness. We then investigated the change in bFGF encapsulation efficiency when the multilayer structure was changed from a tetralayer to a trilayer. As a result, we obtained a highly improved bFGF encapsulation efficiency in the nanofilm using a positively charged layer formed by a blend of Col and Poly2 and a negatively charged poly(acrylic acid) (PAA) layer within a trilayered structure. In particular, we found that a significant amount of adsorbed bFGF was desorbed again during the film fabrication process of a tetralayered nanofilm. In the conventional nanofilm, bFGF was regarded as a polycation and formed a multilayer nanofilm that was composed of a tetralayered structure and was represented as (polycation/polyanion/bFGF/polyanion)(n) where n = number of repeated tetralayers. Here, we suggested that bFGF should not be considered a polycation, rather it should be considered as a small quantity of molecule that exists between the polyanion and polycation layers. In this case, the nanofilm is composed of repeating units of (polycation/polyanion/bFGF/polycation/polyanion), because the amount of adsorbed bFGF is considerably lower than that of other building blocks. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Structure of a Multilayer Nanofilm To Increase the Encapsulation Efficiency of Basic Fibroblast Growth Factor | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/acs.molpharmaceut.7b01099 | - |
dc.identifier.bibliographicCitation | MOLECULAR PHARMACEUTICS, v.15, no.3, pp 1277 - 1283 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000427093600056 | - |
dc.identifier.scopusid | 2-s2.0-85042910005 | - |
dc.citation.endPage | 1283 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 1277 | - |
dc.citation.title | MOLECULAR PHARMACEUTICS | - |
dc.citation.volume | 15 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | multilayer nanofilm | - |
dc.subject.keywordAuthor | basic fibroblast growth factor | - |
dc.subject.keywordAuthor | drug encapsulation efficiency | - |
dc.subject.keywordAuthor | electrostatic interaction | - |
dc.subject.keywordAuthor | molecular adsorption | - |
dc.subject.keywordPlus | SUSTAINED-RELEASE | - |
dc.subject.keywordPlus | CELL-CULTURE | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | MICELLES | - |
dc.subject.keywordPlus | VEHICLES | - |
dc.subject.keywordPlus | HEPARIN | - |
dc.subject.keywordPlus | FILMS | - |
dc.subject.keywordPlus | BFGF | - |
dc.subject.keywordPlus | GEL | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.