Structure of a Multilayer Nanofilm To Increase the Encapsulation Efficiency of Basic Fibroblast Growth Factor
- Authors
- Han, Uiyoung; Hong, Jinkee
- Issue Date
- Mar-2018
- Publisher
- AMER CHEMICAL SOC
- Keywords
- multilayer nanofilm; basic fibroblast growth factor; drug encapsulation efficiency; electrostatic interaction; molecular adsorption
- Citation
- MOLECULAR PHARMACEUTICS, v.15, no.3, pp 1277 - 1283
- Pages
- 7
- Journal Title
- MOLECULAR PHARMACEUTICS
- Volume
- 15
- Number
- 3
- Start Page
- 1277
- End Page
- 1283
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/45313
- DOI
- 10.1021/acs.molpharmaceut.7b01099
- ISSN
- 1543-8384
1543-8392
- Abstract
- In this study, we established the structure of a multilayer nanofilm that more efficiently encapsulates basic fibroblast growth factor (bFGF). First, a positively charged layer material was selected from biocompatible polymers such as collagen (Col), poly(beta-amino ester) (Poly2), and chitosan (Chi), while considering the film thickness. We then investigated the change in bFGF encapsulation efficiency when the multilayer structure was changed from a tetralayer to a trilayer. As a result, we obtained a highly improved bFGF encapsulation efficiency in the nanofilm using a positively charged layer formed by a blend of Col and Poly2 and a negatively charged poly(acrylic acid) (PAA) layer within a trilayered structure. In particular, we found that a significant amount of adsorbed bFGF was desorbed again during the film fabrication process of a tetralayered nanofilm. In the conventional nanofilm, bFGF was regarded as a polycation and formed a multilayer nanofilm that was composed of a tetralayered structure and was represented as (polycation/polyanion/bFGF/polyanion)(n) where n = number of repeated tetralayers. Here, we suggested that bFGF should not be considered a polycation, rather it should be considered as a small quantity of molecule that exists between the polyanion and polycation layers. In this case, the nanofilm is composed of repeating units of (polycation/polyanion/bFGF/polycation/polyanion), because the amount of adsorbed bFGF is considerably lower than that of other building blocks.
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Collections - College of Engineering > School of Chemical Engineering and Material Science > 1. Journal Articles
- College of Natural Sciences > Department of Chemistry > 1. Journal Articles
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