Biomedical Applications of Surface-Enhanced Raman Scattering Spectroscopy
- Authors
- Wang, Rui; Chon, Hyangah; Lee, Sangyeop; Ko, Juhui; Hwang, Joonki; Choi, Namhyun; Cheng, Ziyi; Wang, Xiaokun; Choo, Jaebum
- Issue Date
- 2018
- Publisher
- Elsevier Inc.
- Keywords
- Biomarker; Immunoassay; In vitro diagnostics; Lateral flow assay strip; Microfluidics; Surface-enhanced Raman scattering (SERS)
- Citation
- Frontiers and Advances in Molecular Spectroscopy, pp 307 - 326
- Pages
- 20
- Journal Title
- Frontiers and Advances in Molecular Spectroscopy
- Start Page
- 307
- End Page
- 326
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/45369
- DOI
- 10.1016/B978-0-12-811220-5.00009-5
- ISSN
- 0000-0000
- Abstract
- Many efforts have been invested in the development of rapid and sensitive detection methods for the quantification of disease biomarkers in human blood. Although luminescence- and fluorescence-based detection methods, combined with an automatic sampling system, are routinely used for immunoassays of specific biomarkers, a more sensitive detection technique is needed to track disease progression in its early stage. Recently, a surface-enhanced Raman scattering (SERS)-based immunoassay technique has been considered as a strong candidate to resolve the problem of low sensitivity in conventional luminescence- or fluorescence-based clinical immunoassays. Due to its highly sensitive detection capability and the feasibility of automatic assay, the SERS-based assay technique has strong potential to substitute for currently available fluorescence or luminescence assay systems in clinical laboratory settings. To date, a variety of clinical biomarkers such as proteins, DNAs, hormones, viruses, bacteria, and toxins have been measured using the SERS-based assay technique. Several different types of assay platform have been developed for rapid and reproducible SERS-based assays. In this chapter, four different SERS-based assay platforms-gold-patterned microarray-type substrates, magnetic bead-based assay platforms, microfluidic devices, and lateral flow assay platforms-will be introduced. In addition, the diagnostic feasibility of these assay platforms for various biomarkers will be described. © 2018 Elsevier Inc. All rights reserved.
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