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Studies on the Anti-Oxidative Function of trans-Cinnamaldehyde-Included -Cyclodextrin Complex

Authors
Davaatseren, MunkhtugsJo, Yeon-JiHong, Geun-PyoHur, Haeng JeonPark, SujinChoi, Mi-Jung
Issue Date
Dec-2017
Publisher
MDPI AG
Keywords
trans-cinnamaldehyde; beta-cyclodextrin; self-inclusion; anti-inflammation; antioxidant
Citation
MOLECULES, v.22, no.12
Journal Title
MOLECULES
Volume
22
Number
12
URI
https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/45470
DOI
10.3390/molecules22121868
ISSN
1420-3049
1420-3049
Abstract
trans-Cinnamaldehyde (tCIN), an active compound found in cinnamon, is well known for its antioxidant, anticancer, and anti-inflammatory activities. The -cyclodextrin (-CD) oligomer has been used for a variety of applications in nanotechnology, including pharmaceutical and cosmetic applications. Here, we aimed to evaluate the anti-inflammatory and antioxidant effects of tCIN self-included in -CD complexes (CIs) in lipopolysaccharide (LPS)-treated murine RAW 264.7 macrophages. RAW 264.7 macrophages were treated with increasing concentrations of -CD, tCIN, or CIs for different times. -CD alone did not affect the production of nitric oxide (NO) or reactive oxygen species (ROS). However, both tCIN and CI significantly reduced NO and ROS production. Thus, CIs may have strong anti-inflammatory and antioxidant effects, similar to those of tCIN when used alone.
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