Studies on the Anti-Oxidative Function of trans-Cinnamaldehyde-Included -Cyclodextrin Complex
- Authors
- Davaatseren, Munkhtugs; Jo, Yeon-Ji; Hong, Geun-Pyo; Hur, Haeng Jeon; Park, Sujin; Choi, Mi-Jung
- Issue Date
- Dec-2017
- Publisher
- MDPI AG
- Keywords
- trans-cinnamaldehyde; beta-cyclodextrin; self-inclusion; anti-inflammation; antioxidant
- Citation
- MOLECULES, v.22, no.12
- Journal Title
- MOLECULES
- Volume
- 22
- Number
- 12
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/45470
- DOI
- 10.3390/molecules22121868
- ISSN
- 1420-3049
1420-3049
- Abstract
- trans-Cinnamaldehyde (tCIN), an active compound found in cinnamon, is well known for its antioxidant, anticancer, and anti-inflammatory activities. The -cyclodextrin (-CD) oligomer has been used for a variety of applications in nanotechnology, including pharmaceutical and cosmetic applications. Here, we aimed to evaluate the anti-inflammatory and antioxidant effects of tCIN self-included in -CD complexes (CIs) in lipopolysaccharide (LPS)-treated murine RAW 264.7 macrophages. RAW 264.7 macrophages were treated with increasing concentrations of -CD, tCIN, or CIs for different times. -CD alone did not affect the production of nitric oxide (NO) or reactive oxygen species (ROS). However, both tCIN and CI significantly reduced NO and ROS production. Thus, CIs may have strong anti-inflammatory and antioxidant effects, similar to those of tCIN when used alone.
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Collections - Graduate School > Department of Food Science and Technology > 1. Journal Articles
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