Multilayer Nanofilms via Inkjet Printing for Stabilizing Growth Factor and Designing Desired Cell Developments
- Authors
- Choi, Moonhyun; Park, Hee Ho; Choi, Daheui; Han, Uiyoung; Park, Tai Hyun; Lee, Hwankyu; Park, Juhyun; Hong, Jinkee
- Issue Date
- Jul-2017
- Publisher
- WILEY
- Keywords
- growth factors; induced pluripotent stem (iPS) cells; inkjet; layer-by-layer assembly; nanofilms
- Citation
- ADVANCED HEALTHCARE MATERIALS, v.6, no.14
- Journal Title
- ADVANCED HEALTHCARE MATERIALS
- Volume
- 6
- Number
- 14
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/45556
- DOI
- 10.1002/adhm.201700216
- ISSN
- 2192-2640
2192-2659
- Abstract
- Biologically versatile basic fibroblast growth factor (bFGF), well known for roles of signaling molecules between cells and regulating various cellular processes, has been proven to utilize specific functionalities. However, the remarkable functions are inclinable to dwindle with decrease of bFGFs' activity. In nanoscale, developing thin films with intrinsic characteristics of building molecules can facilitate handling various materials for desired purposes. Fabricating nanofilm and handling sensitive materials without detriment to activity via highly productive manufacturing are significant for practical uses in the field of biomedical applications. Herein, a multilayered nanofilm fabricating system is developed by inkjet printing to incorporate bFGF successfully. It is demonstrated that water mixed with glycerol as biological ink maintains stability of bFGFs through simulation and experimental study. With highly stable bFGFs, the proliferation of human dermal fibroblast is enhanced and the undifferentiated state of induced pluripotent stem cell is maintained by the controlled release of bFGF.
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- Appears in
Collections - College of Engineering > School of Chemical Engineering and Material Science > 1. Journal Articles
- College of Natural Sciences > Department of Chemistry > 1. Journal Articles
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