Quantum Dot-Based Molecularly Imprinted Polymers on Three-Dimensional Origami Paper Microfluidic Chip for Fluorescence Detection of Phycocyanin
- Authors
- Li, Bowei; Zhang, Zhong; Qi, Ji; Zhou, Na; Qin, Song; Choo, Jaebum; Chen, Lingxin
- Issue Date
- Feb-2017
- Publisher
- AMER CHEMICAL SOC
- Keywords
- paper-based microfluidic devices; molecularly imprinted polymers (MIPs); quantum dot; phycocyanin; fluorescence
- Citation
- ACS SENSORS, v.2, no.2, pp 243 - 250
- Pages
- 8
- Journal Title
- ACS SENSORS
- Volume
- 2
- Number
- 2
- Start Page
- 243
- End Page
- 250
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/45598
- DOI
- 10.1021/acssensors.6b00664
- ISSN
- 2379-3694
- Abstract
- In this work, we developed a novel strategy using fluorescent quantum dots (QDs) combined with molecularly imprinted polymers (MIPs) on three-dimensional (3D) origami paper-based microfluidic devices for specific recognition and sensitive detection of phycocyanin. This method can realize the liquid phase of QDs@MIPs being transferred to the solid-phase paper base and achieve easy portability for the analysis. Under optimal conditions, we successfully demonstrated the proposed paper@QDs@MIP5 3D microfluidic chip for the sensitive and selective detection of phycocyanin protein target in a simple and robust manner. Our results revealed that the method exhibited a dynamic response to phycocyanin in the range of 10-50 mg/L with a limit of detection of 2 mg/L. Importantly, this device could provide quantitative information very conveniently and show great potential to be further extended to the detection of other proteins or biomarkers for environmental and food safety research.
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