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Rabies Virus-Inspired Silica-Coated Gold Nanorods as a Photothermal Therapeutic Platform for Treating Brain Tumors
- Authors
- Lee, Changkyu; Hwang, Ha Shin; Lee, Sungin; Kim, Bomi; Kim, Jong Oh; Oh, Kyung Taek; Lee, Eun Seong; Choi, Han-Gon; Youn, Yu Seok
- Issue Date
- Apr-2017
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- brain tumors; gold nanorods; localized surface plasmon resonance; photothermal therapy; rabies virus
- Citation
- ADVANCED MATERIALS, v.29, no.13
- Journal Title
- ADVANCED MATERIALS
- Volume
- 29
- Number
- 13
- ISSN
- 0935-9648
1521-4095
- Abstract
- Rabies virus-inspired silica-coated gold nanorods are fabricated by mimicking size, shape, surface glycoprotein property and in vivo behavior of the rabies virus. These nanorods not only resemble the appearance of the actual rabies virus but also travel into the brain through the neuronal pathway bypassing the bloodbrain barrier, and moreover respond to near-infrared laser (808 nm) irradiation, emit heat, and effectively suppress brain tumors.
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