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Adsorption and desorption of tyrosine kinase inhibitor erlotinib on gold nanoparticles
- Authors
- Anh Thu Ngoc Lam; Yoon, Jinha; Ganbold, Erdene-Ochir; Singh, Dheeraj K.; Kim, Doseok; Cho, Kwang-Hwi; Son, Sang Jun; Choo, Jaebum; Lee, So Yeong; Kim, Sehun; Joo, Sang-Woo
- Issue Date
- 1-Jul-2014
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- Raman spectroscopy; Erlotinib; Gold nanoparticles; Interfacial structures; Density functional theory
- Citation
- JOURNAL OF COLLOID AND INTERFACE SCIENCE, v.425, pp 96 - 101
- Pages
- 6
- Journal Title
- JOURNAL OF COLLOID AND INTERFACE SCIENCE
- Volume
- 425
- Start Page
- 96
- End Page
- 101
- ISSN
- 0021-9797
1095-7103
- Abstract
- We investigated interfacial behaviors of erlotinib (EL) on gold nanoparticles (AuNPs) by means of Raman spectroscopy. The adsorption reactions and structures of EL on AuNP surfaces were examined by UV-Vis absorption spectroscopy and surface-enhanced Raman scattering (SERS). Density functional theory calculations were performed to estimate the energetic stabilities of the drug-AuNP composites. Among the binding units in EL, the acetylenic C equivalent to C group was calculated to be the most strongly binding on the AuNP cluster atoms, consistent with the SERS spectra. The concentration-dependent SERS spectra indicated that similar to 10(-5) M of EL exhibited the highest SERS signals. The attached EL appeared to desorb more efficiently with 2 mM glutathione than with cell culture media. The lack of a strong SERS signal of EL in the darkfield microscopy images of AuNP-EL complexes suggested almost complete desorption of EL inside cells. (C) 2014 Elsevier Inc. All rights reserved.
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