Risk factors for the development of Clostridium difficile colitis in a surgical wardopen access
- Authors
- Min Jeong Kim; Byung Seup Kim; Jae Woo Kwon; So-Eun Ahn; 이승순; 박형철; 이봉화
- Issue Date
- Jul-2012
- Publisher
- 대한외과학회
- Keywords
- Clostridium difficile; Colitis; Risk factors; Colectomy
- Citation
- 대한외과학회지, v.83, no.1, pp 14 - 20
- Pages
- 7
- Journal Title
- 대한외과학회지
- Volume
- 83
- Number
- 1
- Start Page
- 14
- End Page
- 20
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/45997
- DOI
- 10.4174/jkss.2012.83.1.14
- ISSN
- 2288-6575
2093-0488
- Abstract
- Purpose: Clostridium difficile colitis (CDC) is a nosocomial infection. We attempted to discover the risk factors for the development of CDC in patients admitted to our surgical ward. Methods: We conducted a retrospective chart review of all patients admitted to our surgical ward between January 2010 and July 2011. CDC was confirmed when toxin A/B or toxin B polymerase chain reaction was detected in the stool and clinical symptoms, such as diarrhea, were present. We divided patients into the CDC and non-CDC groups, and compared the clinical features between the two groups. Results: The rate of CDC occurrence was 0.4% (19/4,720 patients). Univariate analysis showed that colectomy (P < 0.001), hospital stays longer than 10 days (P < 0.001), aged over 55 years (P < 0.001) and transfer from medical ward (P = 0.009) were significant parameters for CDC. Multivariate analysis showed that colectomy (P < 0.001; odds ratio [OR], 8.405; 95% confidence interval [CI], 2.927 to 24.132) and hospital stays longer than 10 days (P = 0.035; OR, 10.253; 95% CI, 1.176 to 89.392) were high risk factors for CDC occurrence in the surgical ward. Conclusion: The risk factors for CDC in a surgical ward could be colectomy and a long duration of hospitalization. Therefore, clinicians should consider the possibility of CDC when patients undergo colectomy, are admitted for a long time, and have postoperative diarrhea.
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