Recent advances in microfluidic technologies for biochemistry and molecular biology
- Authors
- Cho, Soongwon; Kang, Dong-Ku; Choo, Jaebum; deMello, Andrew J.; Chang, Soo-Ik
- Issue Date
- 30-Nov-2011
- Publisher
- KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
- Keywords
- Biosensors; Emulsion PCR; Genomics; High throughput screening; Microfluidics; Protein-protein interaction; Proteomics
- Citation
- BMB REPORTS, v.44, no.11, pp 705 - 712
- Pages
- 8
- Journal Title
- BMB REPORTS
- Volume
- 44
- Number
- 11
- Start Page
- 705
- End Page
- 712
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/46340
- DOI
- 10.5483/BMBRep.2011.44.11.705
- ISSN
- 1976-6696
1976-670X
- Abstract
- Advances in the fields of proteomics and genomics have necessitated the development of high-throughput screening methods (HTS) for the systematic transformation of large amounts of biological/chemical data into an organized database of knowledge. Microfluidic systems are ideally suited for high-throughput biochemical experimentation since they offer high analytical throughput, consume minute quantities of expensive biological reagents, exhibit superior sensitivity and functionality compared to traditional micro-array techniques and can be integrated within complex experimental work flows. A range of basic biochemical and molecular biological operations have been transferred to chip-based microfluidic formats over the last decade, including gene sequencing, emulsion PCR, immunoassays, electrophoresis, cell-based assays, expression cloning and macromolecule blotting. In this review, we highlight some of the recent advances in the application of microfluidics to biochemistry and molecular biology. [BMB reports 2011; 44(11): 705-712]
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