Changes in the sodium and potassium transporters in the course of chronic renal failure
DC Field | Value | Language |
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dc.contributor.author | Kim, S. | - |
dc.contributor.author | Heo, N.J. | - |
dc.contributor.author | Jung, J.Y. | - |
dc.contributor.author | Son, M.-J. | - |
dc.contributor.author | Jang, H.R. | - |
dc.contributor.author | Lee, J.W. | - |
dc.contributor.author | Oh, Y.K. | - |
dc.contributor.author | Na, K.Y. | - |
dc.contributor.author | Joo, K.W. | - |
dc.contributor.author | Han, J.S. | - |
dc.date.accessioned | 2021-06-18T12:44:17Z | - |
dc.date.available | 2021-06-18T12:44:17Z | - |
dc.date.issued | 2010-07 | - |
dc.identifier.issn | 1660-2137 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/46891 | - |
dc.description.abstract | Background: In chronic renal failure (CRF), residual nephrons can increase their excretion of sodium (Na) and potassium (K). However, the mechanisms of renal Na and K regulation in late-stage CRF have not been clearly investigated. Methods: We examined altered expression of major renal Na and K transporters in Sprague-Dawley rats at 4 and 12 weeks after a 5/6 nephrectomy. Results: CRF rats were azotemic and had gradually increased levels of urinary Na and K excretion over time. At 4 weeks, the abundance of Na-K-2Cl cotransporter (NKCC2), and Na-Cl cotransporter (NCC) in CRF rats increased significantly (477 and 222% of the control, respectively). In contrast, expression of NKCC2 and NCC decreased markedly at 12 weeks (55.4 and 30.8%, respectively). Expression of epithelial Na channel-α increased throughout the whole period. The abundance of renal outer medullary K-channel (ROMK) and Na-K-ATPase did not decrease at 4 weeks, but it was reduced at 12 weeks. Conclusion: We suggest that increased urinary Na excretion in late-stage CRF may be associated with decreased expression of renal Na transporters except ENaC compared to early-stage CRF, and that increased urinary K excretion in the late stage of CRF may not be related to expression of ROMK. Copyright © 2010 S. Karger AG, Basel. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KARGER, ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND | - |
dc.title | Changes in the sodium and potassium transporters in the course of chronic renal failure | - |
dc.type | Article | - |
dc.identifier.doi | 10.1159/000314542 | - |
dc.identifier.bibliographicCitation | Nephron - Physiology, v.115, no.4, pp p31 - p41 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000280462400001 | - |
dc.identifier.scopusid | 2-s2.0-77951959481 | - |
dc.citation.endPage | p41 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | p31 | - |
dc.citation.title | Nephron - Physiology | - |
dc.citation.volume | 115 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | Chronic renal failure | - |
dc.subject.keywordAuthor | Membrane transport proteins | - |
dc.subject.keywordAuthor | Potassium | - |
dc.subject.keywordAuthor | Sodium | - |
dc.subject.keywordPlus | potassium channel | - |
dc.subject.keywordPlus | potassium ion | - |
dc.subject.keywordPlus | Renal outer medullary potassium channel | - |
dc.subject.keywordPlus | sodium chloride cotransporter | - |
dc.subject.keywordPlus | sodium ion | - |
dc.subject.keywordPlus | sodium potassium chloride cotransporter | - |
dc.subject.keywordPlus | unclassified drug | - |
dc.subject.keywordPlus | animal experiment | - |
dc.subject.keywordPlus | animal model | - |
dc.subject.keywordPlus | animal tissue | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | chronic kidney failure | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | histopathology | - |
dc.subject.keywordPlus | immunohistochemistry | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | potassium excretion | - |
dc.subject.keywordPlus | potassium transport | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | protein expression | - |
dc.subject.keywordPlus | rat | - |
dc.subject.keywordPlus | sodium excretion | - |
dc.subject.keywordPlus | sodium transport | - |
dc.subject.keywordPlus | Animals | - |
dc.subject.keywordPlus | Epithelial Sodium Channel | - |
dc.subject.keywordPlus | Kidney Failure, Chronic | - |
dc.subject.keywordPlus | Potassium Channels, Inwardly Rectifying | - |
dc.subject.keywordPlus | Rats | - |
dc.subject.keywordPlus | Rats, Sprague-Dawley | - |
dc.subject.keywordPlus | Sodium Chloride Symporters | - |
dc.subject.keywordPlus | Sodium-Potassium-Chloride Symporters | - |
dc.subject.keywordPlus | Tissue Distribution | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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