Changes in the sodium and potassium transporters in the course of chronic renal failure
- Authors
- Kim, S.; Heo, N.J.; Jung, J.Y.; Son, M.-J.; Jang, H.R.; Lee, J.W.; Oh, Y.K.; Na, K.Y.; Joo, K.W.; Han, J.S.
- Issue Date
- Jul-2010
- Publisher
- KARGER, ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
- Keywords
- Chronic renal failure; Membrane transport proteins; Potassium; Sodium
- Citation
- Nephron - Physiology, v.115, no.4, pp p31 - p41
- Journal Title
- Nephron - Physiology
- Volume
- 115
- Number
- 4
- Start Page
- p31
- End Page
- p41
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/46891
- DOI
- 10.1159/000314542
- ISSN
- 1660-2137
- Abstract
- Background: In chronic renal failure (CRF), residual nephrons can increase their excretion of sodium (Na) and potassium (K). However, the mechanisms of renal Na and K regulation in late-stage CRF have not been clearly investigated. Methods: We examined altered expression of major renal Na and K transporters in Sprague-Dawley rats at 4 and 12 weeks after a 5/6 nephrectomy. Results: CRF rats were azotemic and had gradually increased levels of urinary Na and K excretion over time. At 4 weeks, the abundance of Na-K-2Cl cotransporter (NKCC2), and Na-Cl cotransporter (NCC) in CRF rats increased significantly (477 and 222% of the control, respectively). In contrast, expression of NKCC2 and NCC decreased markedly at 12 weeks (55.4 and 30.8%, respectively). Expression of epithelial Na channel-α increased throughout the whole period. The abundance of renal outer medullary K-channel (ROMK) and Na-K-ATPase did not decrease at 4 weeks, but it was reduced at 12 weeks. Conclusion: We suggest that increased urinary Na excretion in late-stage CRF may be associated with decreased expression of renal Na transporters except ENaC compared to early-stage CRF, and that increased urinary K excretion in the late stage of CRF may not be related to expression of ROMK. Copyright © 2010 S. Karger AG, Basel.
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