Langerhans cell histiocytosis that improved with oral isotretinoin therapyLangerhans Cell Histiocytosis That Improved with Oral Isotretinoin Therapy
- Authors
- Choi, J.H.; Shim, H.C.; Kim, J.H.; Kim, J.B.; Shin, M.S.; Park, H.; Lee, J.S.; Jo, O.J.; Song, K.Y.
- Issue Date
- Oct-2010
- Publisher
- 대한피부과학회
- Keywords
- Isotretinoin; Langerhans cell histiocytosis
- Citation
- Korean Journal of Dermatology, v.48, no.10, pp 893 - 897
- Pages
- 5
- Journal Title
- Korean Journal of Dermatology
- Volume
- 48
- Number
- 10
- Start Page
- 893
- End Page
- 897
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/46899
- ISSN
- 0494-4739
- Abstract
- Langerhans cell histiocytosis (LCH) is a reactive disease in which abnormal Langerhans cells accumulate in various body sites. We report here on a 51-year-old male patient with LCH that was classified as single-system disease (restricted LCH). The skin lesions were a small, deep ulcer in the right inguinal area and multiple erythematous papules scattered on the lower abdomen, and the patient had these lesions for 1 year. The histopathologic examination revealed a dense histiocytic infiltration in the dermis, and most of the cells showed the characteristics of LCH cells. The immunohistochemistry for S-100 protein and CD1a complex all showed positive results. The patient was much improved after surgical excision of the inguinal ulcer and administering oral isotretinoin (20 mg daily) for 8 months, and there was no recurrence. We think retinoid is an effective treatment option for LCH, especially for single system disease.
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