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A gold-nanoparticle-based real-time colorimetric screening method for endonuclease activity and inhibition
- Authors
- Xu, X.; Han, M.S.; Mirkin, C.A.
- Issue Date
- 2007
- Keywords
- Endonucleases; High-throughput screening; Inhibitors; Nanoparticles; Oligonucleotides
- Citation
- Angewandte Chemie - International Edition, v.46, no.19, pp 3468 - 3470
- Pages
- 3
- Journal Title
- Angewandte Chemie - International Edition
- Volume
- 46
- Number
- 19
- Start Page
- 3468
- End Page
- 3470
- ISSN
- 1433-7851
1521-3773
- Abstract
- (Figure Presented) On the small screen: Aggregates of gold nanopartides interconnected by DNA duplexes (see scheme, left) are bluish-purple. Cleavage of the duplexes by deoxyribonuclease I (DNase I) releases the nanoparticles (right), producing a bluish-purple-to-red color change. This color change can be used to monitor the activity (and inhibition) of the enzyme. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
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Collections - College of Natural Sciences > Department of Chemistry > 1. Journal Articles
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