Hyperlipidemia and erectile dysfunction
- Authors
- Kim, SC
- Issue Date
- Sep-2000
- Publisher
- SCIENCE PRESS
- Keywords
- hypercholesterolemia; hypertriglyceridemia; LDL lipoproteins; HDL lipoproteins; superoxide radicals; NO synthase; cavernous smooth muscle; erectile dysfunction
- Citation
- ASIAN JOURNAL OF ANDROLOGY, v.2, no.3, pp 161 - 166
- Pages
- 6
- Journal Title
- ASIAN JOURNAL OF ANDROLOGY
- Volume
- 2
- Number
- 3
- Start Page
- 161
- End Page
- 166
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/47351
- ISSN
- 1008-682X
1745-7262
- Abstract
- We have done consecutive studies to investigate the effects of impaired lipid metabolism on the contractile and relaxation response of cavernous smooth muscles and to elucidate its pathogenesis: 1) incidence of hyperlipidemia in impotent patients; 2) erection response to intracavernous injection of papaverine in impotent patients with hyperlipidemia; 3) relaxation responses of isolated cavernosal smooth muscles to endothelium-independent and endothelium-dependent vasodilators in impotent patients with hypercholesterolemia or hypertriglyceridemia; 4) involvement of superoxide radical in the impaired endothelium-dependent relaxation of cavernous smooth muscle in hypercholesterolemic rabbits; 5) effects of isolated lipoproteins and triglyceride, combined oxidized LDL plus triglyceride, and combined oxidized LDL plus HDL on contractile and relaxation response of rabbit cavernous smooth muscles; 6) involvement of e-NOS in the impaired endothelium-dependent relaxation of cavernous smooth muscle in hypercholesterolemic rabbit. Hypercholesterolemia may cause impairment of endothelium-dependent relaxation. Oxidized LDL is the major causative cholesterol of the impaired relaxation response. A chain reaction, the production of superoxide radicals and functional impairment of eNOS may be a major cause of the functional impairment in the early stages of hypercholesterolemia.
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