beta-Adrenergic modulation of maxi-K channels in vascular smooth muscle via G(i) through a membrane-delimited pathway
- Authors
- Chung, S; Soh, A; Uhm, DY
- Issue Date
- Feb-1999
- Publisher
- SPRINGER VERLAG
- Keywords
- G protein; maxi-K channel; membrane-delimited pathway; pertussis toxin
- Citation
- PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, v.437, no.3, pp 508 - 510
- Pages
- 3
- Journal Title
- PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Volume
- 437
- Number
- 3
- Start Page
- 508
- End Page
- 510
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/47455
- DOI
- 10.1007/s004240050810
- ISSN
- 0031-6768
1432-2013
- Abstract
- Direct modulation of large-conductance Ca2+-activated K+ (maxi-K) channel by receptor-associated G protein in rabbit mesenteric arterial smooth muscle cells was studied using the outside-out patch clamp technique. Applying a beta-adrenoceptor agonist (isoproterenol) increased maxi-K channel activity by 75%, and the effect was almost completely abolished by pretreating the cells with pertussis toxin but not with cholera toxin. When the antibody against G(i) protein was present in the pipette solution the stimulatory effect of isoproterenol disappeared. These results suggest that beta-adrenoceptor stimulation increases maxi-K channel activity via a membrane-delimited pathway, probably through pertussis toxin-sensitive G protein (G(i)).
- Files in This Item
-
- Appears in
Collections - College of Medicine > College of Medicine > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.