Glutathione peroxidase-1 and neuromodulation: Novel potentials of an old enzyme
DC Field | Value | Language |
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dc.contributor.author | Sharma, Garima | - |
dc.contributor.author | Shin, Eun-Joo | - |
dc.contributor.author | Sharma, Naveen | - |
dc.contributor.author | Nah, Seung-Yeol | - |
dc.contributor.author | Huynh Nhu Mai | - |
dc.contributor.author | Bao Trong Nguyen | - |
dc.contributor.author | Jeong, Ji Hoon | - |
dc.contributor.author | Lei, Xin Gen | - |
dc.contributor.author | Kim, Hyoung-Chun | - |
dc.date.accessioned | 2021-06-21T07:40:24Z | - |
dc.date.available | 2021-06-21T07:40:24Z | - |
dc.date.issued | 2021-02 | - |
dc.identifier.issn | 0278-6915 | - |
dc.identifier.issn | 1873-6351 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/47496 | - |
dc.description.abstract | Glutathione peroxidase (GPx) acts in co-ordination with other signaling molecules to exert its own antioxidant role. We have demonstrated the protective effects of GPx,/GPx-1, a selenium-dependent enzyme, on various neurodegenerative disorders (i.e., Parkinson's disease, Alzheimer's disease, cerebral ischemia, and convulsive disorders). In addition, we summarized the recent findings indicating that GPx-1 might play a role as a neuro-modulator in neuropsychiatric conditions, such as, stress, bipolar disorder, schizophrenia, and drug intoxication. In this review, we attempted to highlight the mechanistic scenarios mediated by the GPx/GPx-1 gene in impacting these neurodegenerative and neuropsychiatric disorders, and hope to provide new insights on the therapeutic interventions against these disorders. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | Glutathione peroxidase-1 and neuromodulation: Novel potentials of an old enzyme | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.fct.2020.111945 | - |
dc.identifier.bibliographicCitation | FOOD AND CHEMICAL TOXICOLOGY, v.148 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000610832800017 | - |
dc.identifier.scopusid | 2-s2.0-85098588112 | - |
dc.citation.title | FOOD AND CHEMICAL TOXICOLOGY | - |
dc.citation.volume | 148 | - |
dc.type.docType | Review | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Glutathione peroxidase-1 | - |
dc.subject.keywordAuthor | Neuromodulator | - |
dc.subject.keywordAuthor | Molecular mechanism | - |
dc.subject.keywordAuthor | Neurodegenerative disease | - |
dc.subject.keywordAuthor | Neuropsychiatric disorders | - |
dc.subject.keywordPlus | FAR-INFRARED RAY | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | FACTOR-KAPPA-B | - |
dc.subject.keywordPlus | ISCHEMIA-REPERFUSION INJURY | - |
dc.subject.keywordPlus | INCREASED OXIDATIVE STRESS | - |
dc.subject.keywordPlus | ACID REACTIVE SUBSTANCES | - |
dc.subject.keywordPlus | COCAINE-INDUCED SEIZURES | - |
dc.subject.keywordPlus | TRANSGENIC MOUSE MODEL | - |
dc.subject.keywordPlus | ACUTE RESTRAINT STRESS | - |
dc.subject.keywordPlus | ACTIVITY IN-VITRO | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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