Glutathione peroxidase-1 and neuromodulation: Novel potentials of an old enzyme
- Authors
- Sharma, Garima; Shin, Eun-Joo; Sharma, Naveen; Nah, Seung-Yeol; Huynh Nhu Mai; Bao Trong Nguyen; Jeong, Ji Hoon; Lei, Xin Gen; Kim, Hyoung-Chun
- Issue Date
- Feb-2021
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Glutathione peroxidase-1; Neuromodulator; Molecular mechanism; Neurodegenerative disease; Neuropsychiatric disorders
- Citation
- FOOD AND CHEMICAL TOXICOLOGY, v.148
- Journal Title
- FOOD AND CHEMICAL TOXICOLOGY
- Volume
- 148
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/47496
- DOI
- 10.1016/j.fct.2020.111945
- ISSN
- 0278-6915
1873-6351
- Abstract
- Glutathione peroxidase (GPx) acts in co-ordination with other signaling molecules to exert its own antioxidant role. We have demonstrated the protective effects of GPx,/GPx-1, a selenium-dependent enzyme, on various neurodegenerative disorders (i.e., Parkinson's disease, Alzheimer's disease, cerebral ischemia, and convulsive disorders). In addition, we summarized the recent findings indicating that GPx-1 might play a role as a neuro-modulator in neuropsychiatric conditions, such as, stress, bipolar disorder, schizophrenia, and drug intoxication. In this review, we attempted to highlight the mechanistic scenarios mediated by the GPx/GPx-1 gene in impacting these neurodegenerative and neuropsychiatric disorders, and hope to provide new insights on the therapeutic interventions against these disorders.
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Collections - College of Medicine > College of Medicine > 1. Journal Articles
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