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Mitochondrial Functionality in Male Fertility: From Spermatogenesis to Fertilizationopen access

Authors
Park, Yoo-JinPang, Myung-Geol
Issue Date
Jan-2021
Publisher
MDPI
Keywords
mitochondria; oxidative phosphorylation; spermatozoa; male infertility; testis; epididymis; capacitation; fertilization
Citation
ANTIOXIDANTS, v.10, no.1, pp 1 - 27
Pages
27
Journal Title
ANTIOXIDANTS
Volume
10
Number
1
Start Page
1
End Page
27
URI
https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/47601
DOI
10.3390/antiox10010098
ISSN
2076-3921
2076-3921
Abstract
Mitochondria are structurally and functionally distinct organelles that produce adenosine triphosphate (ATP) through oxidative phosphorylation (OXPHOS), to provide energy to spermatozoa. They can also produce reactive oxidation species (ROS). While a moderate concentration of ROS is critical for tyrosine phosphorylation in cholesterol efflux, sperm-egg interaction, and fertilization, excessive ROS generation is associated with male infertility. Moreover, mitochondria participate in diverse processes ranging from spermatogenesis to fertilization to regulate male fertility. This review aimed to summarize the roles of mitochondria in male fertility depending on the sperm developmental stage (from male reproductive tract to female reproductive tract). Moreover, mitochondria are also involved in testosterone production, regulation of proton secretion into the lumen to maintain an acidic condition in the epididymis, and sperm DNA condensation during epididymal maturation. We also established the new signaling pathway using previous proteomic data associated with male fertility, to understand the overall role of mitochondria in male fertility. The pathway revealed that male infertility is associated with a loss of mitochondrial proteins in spermatozoa, which induces low sperm motility, reduces OXPHOS activity, and results in male infertility.
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Pang, Myung Geol
대학원 (동물생명공학과.)
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