Rediscovery of antimicrobial peptides as therapeutic agentsopen access
- Authors
- Ryu, Minkyung; Park, Jaeyeong; Yeom, Ji-Hyun; Joo, Minju; Lee, Kangseok
- Issue Date
- Feb-2021
- Publisher
- The Korean Society for Mocrobiology / The Korean Society of Virology
- Keywords
- antimicrobial peptide; clinical trial; drug candidate; drug delivery system; SLAY
- Citation
- Journal of Microbiology, v.59, no.2, pp 113 - 123
- Pages
- 11
- Journal Title
- Journal of Microbiology
- Volume
- 59
- Number
- 2
- Start Page
- 113
- End Page
- 123
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/47694
- DOI
- 10.1007/s12275-021-0649-z
- ISSN
- 1225-8873
1976-3794
- Abstract
- In recent years, the occurrence of antibiotic-resistant pathogens is increasing rapidly. There is growing concern as the development of antibiotics is slower than the increase in the resistance of pathogenic bacteria. Antimicrobial peptides (AMPs) are promising alternatives to antibiotics. Despite their name, which implies their antimicrobial activity, AMPs have recently been rediscovered as compounds having antifungal, antiviral, anticancer, antioxidant, and insecticidal effects. Moreover, many AMPs are relatively safe from toxic side effects and the generation of resistant microorganisms due to their target specificity and complexity of the mechanisms underlying their action. In this review, we summarize the history, classification, and mechanisms of action of AMPs, and provide descriptions of AMPs undergoing clinical trials. We also discuss the obstacles associated with the development of AMPs as therapeutic agents and recent strategies formulated to circumvent these obstacles. © 2021, The Microbiological Society of Korea.
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Collections - College of Natural Sciences > Department of Life Science > 1. Journal Articles
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