Poloxamer 407-based Floating Hydrogels for Intravesical Instillation: Statistical Optimization Using Central Composite Design, Gel Erosion, and Drug Release
- Authors
- Yang, Hee Mang; Yoon, Ho Yup; Kim, Chang Hyun; Goo, Yoon Tae; Choi, Ik Joon; Park, Sang-Gue; Chang, In Ho; Choi, Young Wook
- Issue Date
- Jan-2021
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- Poloxamer 407; Floating hydrogel; Gemcitabine; Intravesical instillation; Central composite design
- Citation
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.42, no.1, pp 72 - 79
- Pages
- 8
- Journal Title
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY
- Volume
- 42
- Number
- 1
- Start Page
- 72
- End Page
- 79
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/47707
- DOI
- 10.1002/bkcs.12160
- ISSN
- 0253-2964
1229-5949
- Abstract
- Poloxamer 407 (POL) is widely used as a thermosensitive hydrogel for intravesical instillation. When POL hydrogel is instilled in the bladder, several problems, including urinary tract obstruction, are observed. To overcome this problem, a POL-based floating hydrogel (PFH) system was developed. Sodium bicarbonate (BC) was used as a floating agent. PFH was optimized using a central composite design with two independent variables (X-1 [POL concentration, 42.43%] and X-2 [BC concentration, 5.23%]) and three response factors (Y-1 [floating time, 240.33 s], Y-2 [duration time, 270 min], and Y-3 [viscosity, 110.39 Pa(.)s]). In gel erosion and drug-release studies in vitro, the remaining PFH fraction decreased exponentially with time, while gemcitabine release was biphasic and surface erosion-controlled. A plot of drug release versus gel erosion showed good linearity. Visual observation for floating, gel duration, and dye release supported the time-course behaviors of the PFH, indicating its usefulness in intravesical instillation.
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Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
- College of Business & Economics > Department of Applied Statistics > 1. Journal Articles
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